Guidelines for cell-type heterogeneity quantification based on a comparative analysis of reference-free DNA methylation deconvolution software

BACKGROUND: Cell-type heterogeneity of tumors is a key factor in tumor progression and response to chemotherapy. Tumor cell-type heterogeneity, defined as the proportion of the various cell-types in a tumor, can be inferred from DNA methylation of surgical specimens. However, confounding factors kno...

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Détails bibliographiques
Publié dans:BMC Bioinformatics
Auteurs principaux: Decamps, Clémentine, Privé, Florian, Bacher, Raphael, Jost, Daniel, Waguet, Arthur, Houseman, Eugene Andres, Lurie, Eugene, Lutsik, Pavlo, Milosavljevic, Aleksandar, Scherer, Michael, Blum, Michael G. B., Richard, Magali
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2020
Sujets:
Methodology Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6958785/
https://ncbi.nlm.nih.gov/pubmed/31931698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-019-3307-2
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