Recapitulation of gametic DNA methylation and its post-fertilization maintenance with reassembled DNA elements at the mouse Igf2/H19 locus

BACKGROUND: Paternal allele-specific DNA methylation of the H19 imprinting control region (ICR) regulates imprinted expression of the Igf2/H19 genes. The molecular mechanism by which differential methylation of the H19 ICR is established during gametogenesis and maintained after fertilization, howev...

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Detalhes bibliográficos
Publicado no:Epigenetics Chromatin
Main Authors: Matsuzaki, Hitomi, Kuramochi, Daichi, Okamura, Eiichi, Hirakawa, Katsuhiko, Ushiki, Aki, Tanimoto, Keiji
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6958606/
https://ncbi.nlm.nih.gov/pubmed/31937365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13072-019-0326-1
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