Synthetic DNA fragments bearing ICR cis elements become differentially methylated and recapitulate genomic imprinting in transgenic mice

BACKGROUND: Genomic imprinting is governed by allele-specific DNA methylation at imprinting control regions (ICRs), and the mechanism controlling its differential methylation establishment during gametogenesis has been a subject of intensive research interest. However, recent studies have reported t...

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Dettagli Bibliografici
Pubblicato in:Epigenetics Chromatin
Autori principali: Matsuzaki, Hitomi, Okamura, Eiichi, Kuramochi, Daichi, Ushiki, Aki, Hirakawa, Katsuhiko, Fukamizu, Akiyoshi, Tanimoto, Keiji
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2018
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6027785/
https://ncbi.nlm.nih.gov/pubmed/29958543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13072-018-0207-z
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