Recapitulation of gametic DNA methylation and its post-fertilization maintenance with reassembled DNA elements at the mouse Igf2/H19 locus

BACKGROUND: Paternal allele-specific DNA methylation of the H19 imprinting control region (ICR) regulates imprinted expression of the Igf2/H19 genes. The molecular mechanism by which differential methylation of the H19 ICR is established during gametogenesis and maintained after fertilization, howev...

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Veröffentlicht in:Epigenetics Chromatin
Hauptverfasser: Matsuzaki, Hitomi, Kuramochi, Daichi, Okamura, Eiichi, Hirakawa, Katsuhiko, Ushiki, Aki, Tanimoto, Keiji
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6958606/
https://ncbi.nlm.nih.gov/pubmed/31937365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13072-019-0326-1
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