Tumor suppressor BLU exerts growth inhibition by blocking ERK signaling and disrupting cell cycle progression through RAS pathway interference

We have previously reported that the 3p21 tumor suppressor BLU regulates cell cycle by blocking JNK/MAPK signaling. Another member of the MAPK family, extracellular signal response kinase (ERK), is induced by the RAS-RAF-MEK-ERK pathway and is targeted in anticancer therapy. The effects of BLU on tu...

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Vydáno v:Int J Clin Exp Pathol
Hlavní autoři: Zhang, Xiangning, Shao, Song-Jun, Zhou, Jia-Hui, Li, Xiao-Wu, Zheng, Biying, Huang, Zunnan, He, Zhiwei
Médium: Artigo
Jazyk:Inglês
Vydáno: e-Century Publishing Corporation 2018
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6957978/
https://ncbi.nlm.nih.gov/pubmed/31938097
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