TRPV1 antagonist with high analgesic efficacy: 2-Thio pyridine C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl) propanamides

A series of 2-thio pyridine C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides were investigated as hTRPV1 antagonists. Among them, compound 24S showed stereospecific and excellent TRPV1 antagonism of capsaicin-induced activation. Further, it demonstrated strong anti-allodyni...

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Pubblicato in:Bioorg Med Chem
Autori principali: Ha, Tae-Hwan, Ryu, HyungChul, Kim, Sung-Eun, Kim, Ho Shin, Ann, Jihyae, Tran, Phuong-Thao, Hoang, Van-Hai, Son, Karam, Cui, Minghua, Choi, Sun, Blumberg, Peter M., Frank, Robert, Bahrenberg, Gregor, Schiene, Klaus, Christoph, Thomas, Frormann, Sven, Lee, Jeewoo
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6957258/
https://ncbi.nlm.nih.gov/pubmed/24035514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.08.015
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