Defects in Antiviral T Cell Responses Inflicted by Aging-Associated miR-181a Deficiency

Generation of protective immunity to infections and vaccinations declines with age. Studies in healthy individuals have implicated reduced miR-181a expression in T cells as contributing to this defect. To understand the impact of miR-181a expression on antiviral responses, we examined LCMV infection...

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Pubblicato in:Cell Rep
Autori principali: Kim, Chulwoo, Jadhav, Rohit R., Gustafson, Claire E., Smithey, Megan J., Hirsch, Alec J., Uhrlaub, Jennifer L., Hildebrand, William H., Nikolich-Žugich, Janko, Weyand, Cornelia M., Goronzy, Jörg J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6957231/
https://ncbi.nlm.nih.gov/pubmed/31747595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.10.044
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