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Asymmetric Synthesis of γ-Amino Alcohols by Copper-Catalyzed Hydroamination

Asymmetric synthesis of γ-amino alcohols from unprotected allylic alcohols by a copper-catalyzed hydroamination strategy has been developed. Using easily accessible starting materials, a range of chiral 1,3-amino alcohols were prepared with excellent regio- and enantioselectivity. Further, this prot...

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Vydáno v:Org Lett
Hlavní autoři: Ichikawa, Saki, Buchwald, Stephen L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6956864/
https://ncbi.nlm.nih.gov/pubmed/31625750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.9b03356
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