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A Modified System for the Synthesis of Enantioenriched N-Arylamines through Copper-Catalyzed Hydroamination

Despite significant recent progress in the copper-catalyzed enantioselective hydroamination chemistry, the synthesis of chiral N-arylamines, which are frequently found in natural products and pharmaceuticals, has not been realized. Initial experiments with N-arylhydroxylamine ester electrophiles wer...

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Publicado en:Angew Chem Int Ed Engl
Autores principales: Ichikawa, Saki, Zhu, Shaolin, Buchwald, Stephen L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6033674/
https://ncbi.nlm.nih.gov/pubmed/29847002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201803026
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