2-Alkyl/alkenyl substituted pyridine C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as highly potent TRPV1 antagonists

A series of 2-alkyl/alkenyl pyridine C-region derivatives of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides were investigated as hTRPV1 antagonists. Multiple compounds showed excellent and stereospecific TRPV1 antagonism with better potency than previous lead 2. Among them, compound 15f demons...

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Publicat a:Bioorg Med Chem Lett
Autors principals: Ryu, HyungChul, Seo, Sejin, Cho, Seong-Hee, Kim, Ho Shin, Jung, Aeran, Kang, Dong Wook, Son, Karam, Cui, Minghua, Hong, Sun-hye, Sharma, Pankaz Kumar, Choi, Sun, Blumberg, Peter M., Frank-Foltyn, Robert, Bahrenberg, Gregor, Stockhausen, Hannelore, Schiene, Klaus, Christoph, Thomas, Frormann, Sven, Lee, Jeewoo
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6956567/
https://ncbi.nlm.nih.gov/pubmed/24948568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.05.074
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