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Mycobacterial HflX is a ribosome splitting factor that mediates antibiotic resistance

Antibiotic resistance in bacteria is typically conferred by proteins that function as efflux pumps or enzymes that modify either the drug or the antibiotic target. Here we report an unusual mechanism of resistance to macrolide-lincosamide antibiotics mediated by mycobacterial HflX, a conserved ribos...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Rudra, Paulami, Hurst-Hess, Kelley R., Cotten, Katherine L., Partida-Miranda, Andrea, Ghosh, Pallavi
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6955381/
https://ncbi.nlm.nih.gov/pubmed/31871194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1906748117
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