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Mycobacterial HflX is a ribosome splitting factor that mediates antibiotic resistance

Antibiotic resistance in bacteria is typically conferred by proteins that function as efflux pumps or enzymes that modify either the drug or the antibiotic target. Here we report an unusual mechanism of resistance to macrolide-lincosamide antibiotics mediated by mycobacterial HflX, a conserved ribos...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Rudra, Paulami, Hurst-Hess, Kelley R., Cotten, Katherine L., Partida-Miranda, Andrea, Ghosh, Pallavi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2020
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6955381/
https://ncbi.nlm.nih.gov/pubmed/31871194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1906748117
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