Enhanced expression of β cell Ca(V)3.1 channels impairs insulin release and glucose homeostasis

Voltage-gated calcium 3.1 (Ca(V)3.1) channels are absent in healthy mouse β cells and mediate minor T-type Ca(2+) currents in healthy rat and human β cells but become evident under diabetic conditions. Whether more active Ca(V)3.1 channels affect insulin secretion and glucose homeostasis remains eni...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Yu, Jia, Shi, Yue, Zhao, Kaixuan, Yang, Guang, Yu, Lina, Li, Yuxin, Andersson, Eva-Marie, Ämmälä, Carina, Yang, Shao-Nian, Berggren, Per-Olof
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6955371/
https://ncbi.nlm.nih.gov/pubmed/31871187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1908691117
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