Genetically barcoded SIV reveals the emergence of escape mutations in multiple viral lineages during immune escape

The rapidity of replication coupled with a high mutation rate enables HIV to evade selective pressures imposed by host immune responses. Investigating the ability of HIV to escape different selection forces has generally relied on population-level measures, such as the time to detectable escape muta...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Immonen, Taina T., Camus, Celine, Reid, Carolyn, Fennessey, Christine M., Del Prete, Gregory Q., Davenport, Miles P., Lifson, Jeffrey D., Keele, Brandon F.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6955354/
https://ncbi.nlm.nih.gov/pubmed/31843933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1914967117
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