A regulatory circuit controlling the dynamics of the NFκB cRel phases B cells from proliferation to plasma cell differentiation

Humoral immunity depends on efficient activation of B-cells and their subsequent differentiation to antibody secreting cells (ASCs). The transcription factor NFκB cRel is critical for B-cell proliferation, but incorporating its known regulatory interactions into a mathematical model of the ASC diffe...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Roy, Koushik, Mitchell, Simon, Liu, Yi, Ohta, Sho, Lin, Yu-sheng, Metzig, Marie Oliver, Nutt, Stephen L, Hoffmann, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6955201/
https://ncbi.nlm.nih.gov/pubmed/30850343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2019.02.004
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