Long-Acting Profile of 4 Drugs in 1 Anti-HIV Nanosuspension in Nonhuman Primates for 5 Weeks After a Single Subcutaneous Injection

Daily oral antiretroviral therapy regimens produce limited drug exposure in tissues where residual HIV persists and suffer from poor patient adherence and disparate drug kinetics, which all negatively impact outcomes. To address this, we developed a tissue-and cell-targeted long-acting 4-in-1 nanosu...

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Detalhes bibliográficos
Publicado no:J Pharm Sci
Main Authors: McConnachie, Lisa A., Kinman, Loren M., Koehn, Josefin, Kraft, John C., Lane, Sarah, Lee, Wonsok, Collier, Ann C., Ho, Rodney J.Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6954863/
https://ncbi.nlm.nih.gov/pubmed/29548975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2018.03.005
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