Mechanism-based pharmacokinetic (MBPK) models describe the complex plasma kinetics of three antiretrovirals delivered by a long-acting anti-HIV drug combination nanoparticle formulation

Existing oral antiretroviral (ARV) agents have been shown in human studies to exhibit limited lymph node penetration and lymphatic drug insufficiency. As lymph nodes are a reservoir of HIV, it is critical to deliver and sustain effective levels of ARV combinations in these tissues. To overcome lymph...

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Veröffentlicht in:J Control Release
Hauptverfasser: Kraft, John C., McConnachie, Lisa A., Koehn, Josefin, Kinman, Loren, Sun, Jianguo, Collier, Ann C., Collins, Carol, Shen, Danny D., Ho, Rodney J. Y.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5878144/
https://ncbi.nlm.nih.gov/pubmed/29432823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2018.02.003
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