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Identification of a PAI‐1‐binding site within an intrinsically disordered region of vitronectin
The serine protease inhibitor, plasminogen activator inhibitor Type‐1 (PAI‐1) is a metastable protein that undergoes an unusual transition to an inactive conformation with a short half‐life of only 1–2 hr. Circulating PAI‐1 is bound to a cofactor vitronectin, which stabilizes PAI‐1 by slowing this l...
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| Publicado no: | Protein Sci |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley & Sons, Inc.
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6954738/ https://ncbi.nlm.nih.gov/pubmed/31682300 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3770 |
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