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Type I fatty acid synthase trapped in the octanoyl‐bound state

De novo fatty acid biosynthesis in humans is accomplished by a multidomain protein, the Type I fatty acid synthase (FAS). Although ubiquitously expressed in all tissues, fatty acid synthesis is not essential in normal healthy cells due to sufficient supply with fatty acids by the diet. However, FAS...

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Bibliographic Details
Published in:Protein Sci
Main Authors: Rittner, Alexander, Paithankar, Karthik S., Himmler, Aaron, Grininger, Martin
Format: Artigo
Language:Inglês
Published: John Wiley & Sons, Inc. 2020
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6954729/
https://ncbi.nlm.nih.gov/pubmed/31811668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3797
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