Inhibition of the fungal fatty acid synthase type I multienzyme complex

Fatty acids are among the major building blocks of living cells, making lipid biosynthesis a potent target for compounds with antibiotic or antineoplastic properties. We present the crystal structure of the 2.6-MDa Saccharomyces cerevisiae fatty acid synthase (FAS) multienzyme in complex with the an...

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Detalhes bibliográficos
Main Authors: Johansson, Patrik, Wiltschi, Birgit, Kumari, Preeti, Kessler, Brigitte, Vonrhein, Clemens, Vonck, Janet, Oesterhelt, Dieter, Grininger, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2529065/
https://ncbi.nlm.nih.gov/pubmed/18725634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805827105
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