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Inhibition of the fungal fatty acid synthase type I multienzyme complex
Fatty acids are among the major building blocks of living cells, making lipid biosynthesis a potent target for compounds with antibiotic or antineoplastic properties. We present the crystal structure of the 2.6-MDa Saccharomyces cerevisiae fatty acid synthase (FAS) multienzyme in complex with the an...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2529065/ https://ncbi.nlm.nih.gov/pubmed/18725634 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805827105 |
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