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Downregulation of MYPT1 increases tumor resistance in ovarian cancer by targeting the Hippo pathway and increasing the stemness

BACKGROUND: Ovarian cancer is one of the most common and malignant cancers, partly due to its late diagnosis and high recurrence. Chemotherapy resistance has been linked to poor prognosis and is believed to be linked to the cancer stem cell (CSC) pool. Therefore, elucidating the molecular mechanisms...

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Bibliografske podrobnosti
izdano v:Mol Cancer
Main Authors: Muñoz-Galván, Sandra, Felipe-Abrio, Blanca, Verdugo-Sivianes, Eva M., Perez, Marco, Jiménez-García, Manuel P., Suarez-Martinez, Elisa, Estevez-Garcia, Purificacion, Carnero, Amancio
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6954568/
https://ncbi.nlm.nih.gov/pubmed/31926547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-020-1130-z
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