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Hybridization-mediated off-target effects of splice-switching antisense oligonucleotides
Splice-switching antisense oligonucleotides (ASOs), which bind specific RNA-target sequences and modulate pre-mRNA splicing by sterically blocking the binding of splicing factors to the pre-mRNA, are a promising therapeutic modality to treat a range of genetic diseases. ASOs are typically 15–25 nt l...
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| Publicat a: | Nucleic Acids Res |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6954394/ https://ncbi.nlm.nih.gov/pubmed/31802121 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz1132 |
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