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Deciphering eukaryotic gene-regulatory logic with 100 million random promoters
How transcription factors (TFs) interpret cis-regulatory DNA sequence to control gene expression remains unclear, largely because past studies using native and engineered sequences had insufficient scale. Here, we measure the expression output of >100 million synthetic yeast promoter sequences th...
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| Publicado en: | Nat Biotechnol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6954276/ https://ncbi.nlm.nih.gov/pubmed/31792407 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-019-0315-8 |
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