Deciphering eukaryotic gene-regulatory logic with 100 million random promoters

How transcription factors (TFs) interpret cis-regulatory DNA sequence to control gene expression remains unclear, largely because past studies using native and engineered sequences had insufficient scale. Here, we measure the expression output of >100 million synthetic yeast promoter sequences th...

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Bibliographic Details
Published in:Nat Biotechnol
Main Authors: de Boer, Carl G., Vaishnav, Eeshit Dhaval, Sadeh, Ronen, Abeyta, Esteban Luis, Friedman, Nir, Regev, Aviv
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6954276/
https://ncbi.nlm.nih.gov/pubmed/31792407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-019-0315-8
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