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Deep2Full: Evaluating strategies for selecting the minimal mutational experiments for optimal computational predictions of deep mutational scan outcomes

Performing a complete deep mutational scan with all single point mutations may not be practical, and may not even be required, especially if predictive computational models can be developed. Computational models are however naive to cellular response in the myriads of assay-conditions. In a realisti...

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Vydáno v:PLoS One
Hlavní autoři: Sruthi, C. K., Prakash, Meher
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6954071/
https://ncbi.nlm.nih.gov/pubmed/31923916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0227621
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