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Toward Developing Intuitive Rules for Protein Variant Effect Prediction Using Deep Mutational Scanning Data

[Image: see text] Protein structure and function can be severely altered by even a single amino acid mutation. Predictions of mutational effects using extensive artificial intelligence (AI)-based models, although accurate, remain as enigmatic as the experimental observations in terms of improving in...

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Bibliographic Details
Published in:ACS Omega
Main Authors: Sruthi, Cheloor Kovilakam, Balaram, Hemalatha, Prakash, Meher K.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2020
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7689672/
https://ncbi.nlm.nih.gov/pubmed/33251402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.0c02402
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