Bimodal role of NADPH oxidases in the regulation of biglycan-triggered IL-1β synthesis

Biglycan, a ubiquitous proteoglycan, acts as a danger signal when released from the extracellular matrix. As such, biglycan triggers the synthesis and maturation of interleukin-1β (IL-1β) in a Toll-like receptor (TLR) 2-, TLR4-, and reactive oxygen species (ROS)-dependent manner. Here, we discovered...

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Detalhes bibliográficos
Publicado no:Matrix Biol
Main Authors: Hsieh, Louise Tzung-Harn, Frey, Helena, Nastase, Madalina-Viviana, Tredup, Claudia, Hoffmann, Adrian, Poluzzi, Chiara, Zeng-Brouwers, Jinyang, Manon-Jensen, Tina, Schröder, Katrin, Brandes, Ralf P., Iozzo, Renato V., Schaefer, Liliana
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6953411/
https://ncbi.nlm.nih.gov/pubmed/26689330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.matbio.2015.12.005
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