Structural basis of the transmembrane domain dimerization and rotation in the activation mechanism of the TRKA receptor by nerve growth factor

Tropomyosin-receptor kinases (TRKs) are essential for the development of the nervous system. The molecular mechanism of TRKA activation by its ligand nerve growth factor (NGF) is still unsolved. Recent results indicate that at endogenous levels most of TRKA is in a monomer–dimer equilibrium and that...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Franco, María L., Nadezhdin, Kirill D., Goncharuk, Sergey A., Mineev, Konstantin S., Arseniev, Alexander S., Vilar, Marçal
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2020
Fag:
Molecular Biophysics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6952603/
https://ncbi.nlm.nih.gov/pubmed/31801826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011312
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