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Revising the mechanism of p75NTR activation: intrinsically monomeric state of death domains invokes the "helper" hypothesis

The neurotrophin receptor p75NTR plays crucial roles in neuron development and regulates important neuronal processes like degeneration, apoptosis and cell survival. At the same time the detailed mechanism of signal transduction is unclear. One of the main hypotheses known as the snail-tong mechanis...

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Bibliografische gegevens
Gepubliceerd in:Sci Rep
Hoofdauteurs: Goncharuk, Sergey A., Artemieva, Lilya E., Nadezhdin, Kirill D., Arseniev, Alexander S., Mineev, Konstantin S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2020
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7427093/
https://ncbi.nlm.nih.gov/pubmed/32792564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-70721-8
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