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Revising the mechanism of p75NTR activation: intrinsically monomeric state of death domains invokes the "helper" hypothesis
The neurotrophin receptor p75NTR plays crucial roles in neuron development and regulates important neuronal processes like degeneration, apoptosis and cell survival. At the same time the detailed mechanism of signal transduction is unclear. One of the main hypotheses known as the snail-tong mechanis...
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| Publicado en: | Sci Rep |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7427093/ https://ncbi.nlm.nih.gov/pubmed/32792564 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-70721-8 |
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