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‘Trim’ming PolyQ proteins with engineered PML
Protein abnormalities are the major cause of neurodegenerative diseases such as SCA (Spinocerebellar Ataxia). Protein misfolding and impaired degradation leads to the build-up of protein aggregates inside the cell, which may further cause cellular degeneration. Reducing levels of either the soluble...
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| Publicat a: | Biotechnol Bioeng |
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| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6952540/ https://ncbi.nlm.nih.gov/pubmed/31710088 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bit.27220 |
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