Comparative Investigation into Formycin A and Pyrazofurin A Biosynthesis Reveals Branch Pathways for the Construction of C-Nucleoside Scaffolds

Formycin A (FOR-A) and pyrazofurin A (PRF-A) are purine-related C-nucleoside antibiotics in which ribose and a pyrazole-derived base are linked by a C-glycosidic bond. However, the logic underlying the biosynthesis of these molecules has remained largely unexplored. Here, we report the discovery of...

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Detalhes bibliográficos
Publicado no:Appl Environ Microbiol
Main Authors: Zhang, Meng, Zhang, Peichao, Xu, Gudan, Zhou, Wenting, Gao, Yaojie, Gong, Rong, Cai, You-Sheng, Cong, Hengjiang, Deng, Zixin, Price, Neil P. J., Mao, Xiangzhao, Chen, Wenqing
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Genetics and Molecular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6952237/
https://ncbi.nlm.nih.gov/pubmed/31676476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.01971-19
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