Comparative Investigation into Formycin A and Pyrazofurin A Biosynthesis Reveals Branch Pathways for the Construction of C-Nucleoside Scaffolds

Formycin A (FOR-A) and pyrazofurin A (PRF-A) are purine-related C-nucleoside antibiotics in which ribose and a pyrazole-derived base are linked by a C-glycosidic bond. However, the logic underlying the biosynthesis of these molecules has remained largely unexplored. Here, we report the discovery of...

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Dades bibliogràfiques
Publicat a:Appl Environ Microbiol
Autors principals: Zhang, Meng, Zhang, Peichao, Xu, Gudan, Zhou, Wenting, Gao, Yaojie, Gong, Rong, Cai, You-Sheng, Cong, Hengjiang, Deng, Zixin, Price, Neil P. J., Mao, Xiangzhao, Chen, Wenqing
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2020
Matèries:
Genetics and Molecular Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6952237/
https://ncbi.nlm.nih.gov/pubmed/31676476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.01971-19
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