The thiocyanate analog selenocyanate is a more potent antimicrobial pro-drug that also is selectively detoxified by the host

A hallmark of cystic fibrosis (CF) lung pathology is an increased susceptibility to pulmonary infections. Thiocyanate ((−)SCN) is an endogenous component of the innate immunity’s peroxidase system that converts (−)SCN to the antimicrobial agent hypothiocyanite (HOSCN). We have previously shown that...

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Veröffentlicht in:Free Radic Biol Med
Hauptverfasser: Day, Brian J., Bratcher, Preston E., Chandler, Joshua D., Kilgore, Matthew B., Min, Elysia, LiPuma, John J., Hondal, Robert J., Nichols, David P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6951815/
https://ncbi.nlm.nih.gov/pubmed/31740228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2019.11.016
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