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An in silico exploration of combining Interleukin-12 with Oxaliplatin to treat liver-metastatic colorectal cancer

BACKGROUND: Combining anti-cancer therapies with orthogonal modes of action, such as direct cytotoxicity and immunostimulatory, hold promise for expanding clinical benefit to patients with metastatic disease. For instance, a chemotherapy agent Oxaliplatin (OXP) in combination with Interleukin-12 (IL...

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Pubblicato in:BMC Cancer
Autori principali: Wang, Qing, Wang, Zhijun, Wu, Yan, Klinke, David J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6950805/
https://ncbi.nlm.nih.gov/pubmed/31914948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-019-6500-9
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