A Natural Quinazoline Derivative from Marine Sponge Hyrtios erectus Induces Apoptosis of Breast Cancer Cells via ROS Production and Intrinsic or Extrinsic Apoptosis Pathways

Here, we report the therapeutic potential of a natural quinazoline derivative (2-chloro-6-phenyl-8H-quinazolino[4,3-b]quinazolin-8-one) isolated from marine sponge Hyrtios erectus against human breast cancer. The cytotoxicity of the compound was investigated on a human breast carcinoma cell line (MC...

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Détails bibliographiques
Publié dans:Mar Drugs
Auteurs principaux: De, Arun Kumar, Muthiyan, Ramachandran, Mondal, Samiran, Mahanta, Nilkamal, Bhattacharya, Debasis, Ponraj, Perumal, Muniswamy, Kangayan, Kundu, Anandamoy, Kundu, Madhu Sudhan, Sunder, Jai, Karunakaran, Dhanasekar, Bera, Asit Kumar, Roy, Sibnarayan Dam, Malakar, Dhruba
Format: Artigo
Langue:Inglês
Publié: MDPI 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6950652/
https://ncbi.nlm.nih.gov/pubmed/31771152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md17120658
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