A Natural Quinazoline Derivative from Marine Sponge Hyrtios erectus Induces Apoptosis of Breast Cancer Cells via ROS Production and Intrinsic or Extrinsic Apoptosis Pathways

Here, we report the therapeutic potential of a natural quinazoline derivative (2-chloro-6-phenyl-8H-quinazolino[4,3-b]quinazolin-8-one) isolated from marine sponge Hyrtios erectus against human breast cancer. The cytotoxicity of the compound was investigated on a human breast carcinoma cell line (MC...

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Publicado no:Mar Drugs
Main Authors: De, Arun Kumar, Muthiyan, Ramachandran, Mondal, Samiran, Mahanta, Nilkamal, Bhattacharya, Debasis, Ponraj, Perumal, Muniswamy, Kangayan, Kundu, Anandamoy, Kundu, Madhu Sudhan, Sunder, Jai, Karunakaran, Dhanasekar, Bera, Asit Kumar, Roy, Sibnarayan Dam, Malakar, Dhruba
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6950652/
https://ncbi.nlm.nih.gov/pubmed/31771152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md17120658
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