Imidazolopiperazines: Hit to Lead Optimization of New Antimalarial Agents

[Image: see text] Starting from a hit series from a GNF compound library collection and based on a cell-based proliferation assay of Plasmodium falciparum, a novel imidazolopiperazine scaffold was optimized. SAR for this series of compounds is discussed, focusing on optimization of cellular potency...

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Published in:J Med Chem
Main Authors: Wu, Tao, Nagle, Advait, Kuhen, Kelli, Gagaring, Kerstin, Borboa, Rachel, Francek, Caroline, Chen, Zhong, Plouffe, David, Goh, Anne, Lakshminarayana, Suresh B., Wu, Jeanette, Ang, Hui Qing, Zeng, Peiting, Kang, Min Low, Tan, William, Tan, Maria, Ye, Nicole, Lin, Xuena, Caldwell, Christopher, Ek, Jared, Skolnik, Suzanne, Liu, Fenghua, Wang, Jianling, Chang, Jonathan, Li, Chun, Hollenbeck, Thomas, Tuntland, Tove, Isbell, John, Fischli, Christoph, Brun, Reto, Rottmann, Matthias, Dartois, Veronique, Keller, Thomas, Diagana, Thierry, Winzeler, Elizabeth, Glynne, Richard, Tully, David C., Chatterjee, Arnab K.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2011
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6950218/
https://ncbi.nlm.nih.gov/pubmed/21644570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm2003359
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