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Wiskott-Aldrich syndrome protein senses irradiation-induced DNA damage to coordinate the cell-protective Golgi dispersal response in human T and B lymphocytes

BACKGROUND: Wiskott-Aldrich syndrome (WAS) is an X-linked primary immunodeficiency disorder resulting from WASp deficiency. WAS lymphocytes manifest increased DNA damage and lymphopenia from cell death, yet how WASp influences DNA damage-linked cell survival is unknown. A recently-described mechanis...

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Bibliografiske detaljer
Udgivet i:J Allergy Clin Immunol
Main Authors: Wen, Kuo-Kuang, Han, Seong-Su, Vyas, Yatin M.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6949418/
https://ncbi.nlm.nih.gov/pubmed/31604087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2019.09.026
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