Apralogs: Apramycin 5-O-Glycosides and Ethers with Improved Antibacterial Activity and Ribosomal Selectivity and Reduced Susceptibility to the Aminoacyltranserferase (3)-IV Resistance Determinant.

Apramycin is a structurally unique member of the 2-deoxystreptamine class of aminoglycoside antibiotics characterized by a mono-substituted 2-deoxystreptamine ring that carries an unusual bicyclic eight-carbon dialdose moiety. Because of its unusual structure apramycin is not susceptible to the most...

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Veröffentlicht in:J Am Chem Soc
Hauptverfasser: Quirke, Jonathan C. K., Rajasekaran, Parasuraman, Sarpe, Vikram A, Sonousi, Amr, Osinnii, Ivan, Gysin, Marina, Haldimann, Klara, Fang, Qiao-Jun, Shcherbakov, Dimitri, Hobbie, Sven N., Sha, Su-Hua, Schacht, Jochen, Vasella, Andrea, Böttger, Erik C., Crich, David
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6949408/
https://ncbi.nlm.nih.gov/pubmed/31790244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b11601
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