ULK1 phosphorylates Exo70 to suppress breast cancer metastasis

Increased expression of protein kinase ULK1 was reported to negatively correlate with breast cancer metastasis. Here we report that ULK1 suppresses the migration and invasion of human breast cancer cells. The suppressive effect is mediated through direct phosphorylation of Exo70, a key component of...

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Publié dans:Nat Commun
Auteurs principaux: Mao, Liyuan, Zhan, Yan-yan, Wu, Bin, Yu, Qiang, Xu, Liang, Hong, Xiaoting, Zhong, Linhai, Mi, Panying, Xiao, Li, Wang, Xinquan, Cao, Hanwei, Zhang, Wenqing, Chen, Binbin, Xiang, Jingzhou, Mei, Kunrong, Radhakrishnan, Ravi, Guo, Wei, Hu, Tianhui
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6949295/
https://ncbi.nlm.nih.gov/pubmed/31913283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13923-7
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