ULK1 phosphorylates Exo70 to suppress breast cancer metastasis

Increased expression of protein kinase ULK1 was reported to negatively correlate with breast cancer metastasis. Here we report that ULK1 suppresses the migration and invasion of human breast cancer cells. The suppressive effect is mediated through direct phosphorylation of Exo70, a key component of...

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Pubblicato in:Nat Commun
Autori principali: Mao, Liyuan, Zhan, Yan-yan, Wu, Bin, Yu, Qiang, Xu, Liang, Hong, Xiaoting, Zhong, Linhai, Mi, Panying, Xiao, Li, Wang, Xinquan, Cao, Hanwei, Zhang, Wenqing, Chen, Binbin, Xiang, Jingzhou, Mei, Kunrong, Radhakrishnan, Ravi, Guo, Wei, Hu, Tianhui
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6949295/
https://ncbi.nlm.nih.gov/pubmed/31913283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13923-7
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