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ULK1 phosphorylates Exo70 to suppress breast cancer metastasis

Increased expression of protein kinase ULK1 was reported to negatively correlate with breast cancer metastasis. Here we report that ULK1 suppresses the migration and invasion of human breast cancer cells. The suppressive effect is mediated through direct phosphorylation of Exo70, a key component of...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Mao, Liyuan, Zhan, Yan-yan, Wu, Bin, Yu, Qiang, Xu, Liang, Hong, Xiaoting, Zhong, Linhai, Mi, Panying, Xiao, Li, Wang, Xinquan, Cao, Hanwei, Zhang, Wenqing, Chen, Binbin, Xiang, Jingzhou, Mei, Kunrong, Radhakrishnan, Ravi, Guo, Wei, Hu, Tianhui
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6949295/
https://ncbi.nlm.nih.gov/pubmed/31913283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13923-7
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