Predicting the mutations generated by repair of Cas9-induced double-strand breaks

The DNA mutation produced by cellular repair of a CRISPR/Cas9-generated double-strand break determines its phenotypic effect. It is known that the mutational outcomes are not random, and depend on DNA sequence at the targeted location. Here we systematically study the influence of flanking DNA seque...

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Detalhes bibliográficos
Publicado no:Nat Biotechnol
Main Authors: Allen, Felicity, Crepaldi, Luca, Alsinet, Clara, Strong, Alexander J., Kleshchevnikov, Vitalii, De Angeli, Pietro, Palenikova, Petra, Khodak, Anton, Kiselev, Vladimir, Kosicki, Michael, Bassett, Andrew R., Harding, Heather, Galanty, Yaron, Muñoz-Martínez, Francisco, Metzakopian, Emmanouil, Jackson, Stephen P., Parts, Leopold
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6949135/
https://ncbi.nlm.nih.gov/pubmed/30480667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.4317
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