CTNNB1/β-catenin dysfunction contributes to adiposity by regulating the cross-talk of mature adipocytes and preadipocytes

Overnutrition results in adiposity and chronic inflammation with expansion of white adipose tissue (WAT). However, genetic factors controlling fat mass and adiposity remain largely undetermined. We applied whole-exome sequencing in young obese subjects and identified rare gain-of-function mutations...

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Bibliografske podrobnosti
izdano v:Sci Adv
Main Authors: Chen, Maopei, Lu, Peng, Ma, Qinyun, Cao, Yanan, Chen, Na, Li, Wen, Zhao, Shaoqian, Chen, Banru, Shi, Juan, Sun, Yingkai, Shen, Hongbin, Sun, Liangdan, Shen, Juan, Liao, Qijun, Zhang, Yifei, Hong, Jie, Gu, Weiqiong, Liu, Ruixin, Ning, Guang, Wang, Weiqing, Wang, Jiqiu
Format: Artigo
Jezik:Inglês
Izdano: American Association for the Advancement of Science 2020
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6949042/
https://ncbi.nlm.nih.gov/pubmed/31934629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aax9605
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