CTNNB1/β-catenin dysfunction contributes to adiposity by regulating the cross-talk of mature adipocytes and preadipocytes

Overnutrition results in adiposity and chronic inflammation with expansion of white adipose tissue (WAT). However, genetic factors controlling fat mass and adiposity remain largely undetermined. We applied whole-exome sequencing in young obese subjects and identified rare gain-of-function mutations...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Chen, Maopei, Lu, Peng, Ma, Qinyun, Cao, Yanan, Chen, Na, Li, Wen, Zhao, Shaoqian, Chen, Banru, Shi, Juan, Sun, Yingkai, Shen, Hongbin, Sun, Liangdan, Shen, Juan, Liao, Qijun, Zhang, Yifei, Hong, Jie, Gu, Weiqiong, Liu, Ruixin, Ning, Guang, Wang, Weiqing, Wang, Jiqiu
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6949042/
https://ncbi.nlm.nih.gov/pubmed/31934629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aax9605
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