Neuron-based high-content assay and screen for CNS active mitotherapeutics

Impaired mitochondrial dynamics and function are hallmarks of many neurological and psychiatric disorders, but direct screens for mitotherapeutics using neurons have not been reported. We developed a multiplexed and high-content screening assay using primary neurons and identified 67 small-molecule...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Varkuti, Boglarka H., Kepiro, Miklos, Liu, Ze, Vick, Kyle, Avchalumov, Yosef, Pacifico, Rodrigo, MacMullen, Courtney M., Kamenecka, Theodore M., Puthanveettil, Sathyanarayanan V., Davis, Ronald L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6949038/
https://ncbi.nlm.nih.gov/pubmed/31934620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaw8702
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