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Novel, primate-specific PDE10A isoform highlights gene expression complexity in human striatum with implications on the molecular pathology of bipolar disorder

Bipolar disorder is a highly heritable neuropsychiatric disorder affecting nearly 2.5% of the population. Prior genetic studies identified a panel of common and rare single-nucleotide polymorphisms associated with the disease that map to the first intron of the PDE10A gene. RNA sequencing of striata...

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Detalhes bibliográficos
Publicado no:Transl Psychiatry
Main Authors: MacMullen, C M, Vick, K, Pacifico, R, Fallahi-Sichani, M, Davis, R L
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872433/
https://ncbi.nlm.nih.gov/pubmed/26905414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tp.2016.3
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