Doublecortin-like Kinase 1 Regulates α-Synuclein Levels and Toxicity

α-Synuclein (α-Syn) accumulation is a pathological hallmark of Parkinson's disease. Duplications and triplications of SNCA, the gene coding for α-Syn, cause genetic forms of the disease, which suggests that increased α-Syn dosage can drive PD. To identify the proteins that regulate α-Syn, we pr...

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Détails bibliographiques
Publié dans:J Neurosci
Auteurs principaux: Vázquez-Vélez, Gabriel E., Gonzales, Kristyn A., Revelli, Jean-Pierre, Adamski, Carolyn J., Alavi Naini, Fatemeh, Bajić, Aleksandar, Craigen, Evelyn, Richman, Ronald, Heman-Ackah, Sabrina M., Wood, Matthew J.A., Rousseaux, Maxime W.C., Zoghbi, Huda Y.
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2020
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6948939/
https://ncbi.nlm.nih.gov/pubmed/31748376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1076-19.2019
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