Rb1/Rbl1/Vhl loss induces mouse subretinal angiomatous proliferation and hemangioblastoma

Von Hippel–Lindau (Vhl) protein inhibits hypoxia-inducible factor (Hif), yet its deletion in murine retina does not cause the extensive angiogenesis expected with Hif induction. The mechanism is unclear. Here we show that retinoblastoma tumor suppressor (Rb1) constrains expression of Hif target gene...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Wei, Ran, Ren, Xiang, Kong, Hongyu, Lv, Zhongping, Chen, Yongjiang, Tang, Yunjing, Wang, Yujiao, Xiao, Lirong, Yu, Tao, Hacibekiroglu, Sabiha, Liang, Chen, Nagy, Andras, Bremner, Rod, Chen, Danian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6948866/
https://ncbi.nlm.nih.gov/pubmed/31613797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.127889
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