Sporadic hemangioblastomas are characterized by cryptic VHL inactivation

Hemangioblastomas consist of 10-20% neoplastic “stromal” cells within a vascular tumor cell mass of reactive pericytes, endothelium and lymphocytes. Familial cases of central nervous system hemangioblastoma uniformly result from mutations in the Von Hippel-Lindau (VHL) gene. In contrast, inactivatio...

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Bibliografiske detaljer
Udgivet i:Acta Neuropathol Commun
Main Authors: Shankar, Ganesh M, Taylor-Weiner, Amaro, Lelic, Nina, Jones, Robert T, Kim, James C, Francis, Joshua M, Abedalthagafi, Malak, Borges, Lawrence F, Coumans, Jean-Valery, Curry, William T, Nahed, Brian V, Shin, John H, Paek, Sun Ha, Park, Sung-Hye, Stewart, Chip, Lawrence, Michael S, Cibulskis, Kristian, Thorner, Aaron R, Van Hummelen, Paul, Stemmer-Rachamimov, Anat O, Batchelor, Tracy T, Carter, Scott L, Hoang, Mai P, Santagata, Sandro, Louis, David N, Barker, Fred G, Meyerson, Matthew, Getz, Gad, Brastianos, Priscilla K, Cahill, Daniel P
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4297409/
https://ncbi.nlm.nih.gov/pubmed/25589003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-014-0167-x
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