Cathepsin K inhibition-induced mitochondrial ROS enhances sensitivity of cancer cells to anti-cancer drugs through USP27x-mediated Bim protein stabilization

Cathepsin K (Cat K) is expressed in cancer cells, but the effect of Cat K on apoptosis is still elusive. Here, we showed that inhibition of Cat K sensitized the human carcinoma cells to anti-cancer drug through up-regulation of Bim. Inhibition of Cat K increased USP27x expression, and knock down of...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Seo, Seung Un, Woo, Seon Min, Kim, Min Wook, Lee, Hyun-Shik, Kim, Sang Hyun, Kang, Sun Chul, Lee, Eun-Woo, Min, Kyoung-jin, Kwon, Taeg Kyu
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6948260/
https://ncbi.nlm.nih.gov/pubmed/31901727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2019.101422
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